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There are two main forms of vitamin A in the human diet. Many foods contain beta-carotene and it is also an FDA approved nutritional supplement. [1] 2. β-Carotene supplementation may cause harm rather than produce benefit in healthy people. From this derived spectrum, an estimate of skin carotenoid concentration can be determined that is in the same range as reports using skin biopsies and HPLC analyses (86). In cosmetics and personal care products, Beta-Carotene functions as a colorant and as a skin conditioning agent - miscellaneous. Interestingly, β-carotene, the precursor of vitamin A, is not toxic. It’s converted in the body to vitamin A, a powerful antioxidant that plays a critical role in maintaining healthy vision, skin and neurological function. However, excess carotene may turn skin yellow [43]. Too little beta carotene or too much both have their share of risk, which makes genetic testing for vitamin A needs important. Vitamin A is found in two primary forms: active vitamin A and beta-carotene. Vitamin A undergoes several transformations in the body before it becomes usable (biologically active) to skin cells. The main function of melanin is to absorb ultraviolet (UV) radiation to protect us from its harmful effects. phagocytized by keratinocytes. The melanin is transferred into the keratinocytes via a cellular vesicle called a melanosome (Figure 7). In relation, preparations have been developed including β-carotene for use prior to sun exposure. Melanin soaks up UV rays, absorbing them, which makes the color of our skin change. The most common type of pro-vitamin A is beta-carotene. The administration of 30 mg of β-carotene per day for 10 weeks enhances yellow coloration in the skin all over the body and reduces erythema. The conversion of beta-carotene (provitamin A) to 2 molecules of vitamin A (retinol) is accelerated by thyroxine and hyperthyroidism, respectively. The characteristic yellow tint of the skin in hypothyroidism is due to hyper-beta-carotenemia. Carotenemia treatment. .. 2) The amount of carotene (yellow) in the epidermis and subcutaneous tissue 3) The amount of oxygen bound to hemoglobin (red blood cell pigment) in the dermal blood cells. Carotenemia Treatment. Skin color is … Are you converting sufficient beta-carotene to vitamin A? etc., there are abundant β-carotene. Those who took beta carotene had benefits associated with memory and cognitive function. Beta-carotene (C40H56) is one of the carotenoids and an orange-soluble fat-soluble compound. In fact, beta-carotene is the most common form of carotene and main safe dietary source of vitamin A. This is another very important function of the skin. Except for Retinoic Acid, all of the above forms of Vitamin A must go through an enzymatic conversion process before it can be made bioavailable in the skin. It’s a powerful antioxidant that helps protect the lungs, eyes, skin, cardiovascular system and immune system. Lascari AD. It is influenced by several pigments, including melanin, carotene and haemoglobin. Carotene and hemoglobin provide different services to the integumentary system. most responsible for the skin color of dark-skinned people. In skin care products, beta-carotene is used for its antioxidant properties, its ability to protect the skin from sun damage (note that it is not intended for, or should be used as, a method of sun protection), and its ability to help even the skin tone, deeming it an active "anti-aging" ingredient. BCMO1 is a cytoplasmic protein [98] found in relatively high amounts in the epithelium of a number of tissues and organs including the stomach, small intestine, colon, and endometrium, as well as the skin epidermis, the liver hepatocytes, and pancreatic acinar cells [99]. 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